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J Control Rel 42:83–92 87. Langer R (1983) Implantable controlled release systems. Pharm Ther 21:35–51 88. Li Y, Shawgo RS, Tyler B et al (2004) In vivo release from a drug delivery MEMS device. J Control Rel 100:211–219 89. Grüntzig A, Senning A, Siegenthaler WE (1979) Nonoperative dilatation of coronary-artery stenosis: percutaneous transluminal coronary angioplasty. New Engl J Med 301:61–68 90. Muller DWM, Topol EJ (1991) Implantable devices in the coronary artery. Trends Cardiovasc Med 1:225–232 91.

Brockedon’s Patent. Process Pharm J 3:1843–1844 14. Pariente L (1996) Comprimés Chap. 6 in Naissance et Evolution de Quinze Formes Pharmaceutiques. Editions Louis Pariente, Paris, pp 94–118 15. Dunton J (1875) Improvement in the manufacture of pills. US Patent 168,240 16. Carter C (1878) Improvement in coated compressed medicaments. US Patent 207,013 17. Ellzey EF (National Aniline Company) (1931) Device for administering medicaments. T. Florence 18. Kraus F (1870) Improvements in putting up medicines.

It was probably not until the advent of penicillin that inhalation became an important route of delivery. Nebulizers powered by compressed air or oxygen produced particles from the visible to the submicron in diameter. Mutch’s exposition on the inhalation of chemotherapeutic substances discusses the fate of particles in some detail [95] and refers to early in vitro experiments by Heubner [96] on aerosol particle deposition. Presaging pharmacopeial artificial throats and other valuable apparatus in use today, the complex glass apparatus of Heubner with “bends, forks and narrowings and expansions” to resemble the complexity of the respiratory tract, demonstrated that particles of 5 mm reached its furthermost ends.

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Brazil Biotech Map 2011 by Br Biotech

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