By M. Mahdavi
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Construction of this quantity of the instruction manual. If this joint company has succeeded it really is because of their competence, wisdom and alertness, for the editor's function is purely that of a coordinator. My thank you also are because of Springer-Verlag, the publishers, who gave me each attainable advice in seeing this quantity to final touch.
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The proposal was to host the EBI on a park, newly purchased by the Wellcome Trust, at Hinxton, on the outskirts of Cambridge. The Trust and MRC had agreed each to fund half of the initial capital costs of creating a complete genomics infrastructure on this site, which would also include the newly established Sanger Centre (which, by then, had become embroiled in the HGP) and the Human Genome Mapping Project Resource Centre (Dickson & Abbott, 1993). With its “clear commitment from all levels of the UK scientific community and Government”, the UK bid won over both Uppsala and the alternative location in Heidelberg, directly adjacent to the EMBL; it was accepted by Council in March 1993.
C. (1997) The Protein Information Resource (PIR) and the PIRInternational Protein Sequence Database. , 25(1), 24-28. R. J. (1980) Steps towards computer analysis of nucleotide sequences. Science, 209, 1322-1328. , Dujon, B. et al. (1996) Life with 6000 genes. Science, 274, 546-567. , Blanchard, M. et al. (2001). Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58. Science, 294, 2323-2328. H. N. (1986) The EMBL data library. , 14(1), 5–9. Harvey, M. & McMeekin, A.
Trying to sensibly merge apparently equivalent database entries that, in fact, defined specific families, domains within those families, or even repeats within those domains, presented enormous challenges. In the beginning, InterPro therefore focused on amalgamating databases that offered some level of annotation, to facilitate the integration process. Over the years, further partners joined the InterPro consortium, as illustrated in Figure 5. Today, with 12 primary sources, the integration challenges are legion (some of the complexity can be understood from the list of partners, and the numbers of their signatures that InterPro has incorporated, shown in Table 3)!
Bioinformatics - Trends and Methodologies by M. Mahdavi