By Keiji Maruoka
Edited via the prime specialist at the subject, this is often the 1st e-book to offer the most recent advancements during this interesting box. along the theoretical facets, the pinnacle participants offer useful protocols to provide readers extra vital info in a different way unavailable. A needs to for each man made chemist in academia and undefined.
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And Ricci, A. (2005) Angew. , 117, 8189; (2005) Angew. Chem. Int. , 44, 7975. , Laso, A. and López, R. (2005) J. Am. Chem. , 127, 17622. , Pettersen, D. and Ricci, A. (2006) J. Org. , 71, 9869. , Bhanthumnavin, W. and Vilaivan, T. (2004) Synth. , 34, 3147. M. and Prabhakar, S. , 37, 3183. 47 Murugan, E. and Siva, A. (2005) Synthesis, 2022. H. O. (2006) Chem. , 5045. , Ricci, A. and Sgarzani, V. (2006) Adv. Synth. , 348, 2043. , Ishida, T. and Shioiri, T. , 40, 4215. 1 Introduction Phase-transfer catalysis has been recognized as one of the most powerful synthetic tools for establishing practical protocols because it offers several advantages, such as operational simplicity, mild conditions with aqueous media, suitability for large-scale reaction, and an environmentally benign nature.
23) . 8 Aziridination The asymmetric aziridination of a,b-unsaturated carboxylic acid derivatives is a direct route to optically active aza-cyclic a-amino acids, and this class of chiral aziridines can also be used as chiral building blocks for the preparation of other amino acids, b-lactams, and alkaloids. 24) . 25) . 26 alkyl radicals to glyoxylate oxime ether 28 under biphasic conditions, based on the use of chiral quaternary ammonium hypophosphite 27 as a mediator and Et3B/O2 as an initiator.
This protocol requires the use of a stoichiometric amount of chiral ammonium salt (non-catalytic) . 6 Asymmetric Alkylation The asymmetric a-alkylation of carbonyl compounds is a fundamental reaction. Under PTC conditions, acidic substrates such as phenylketone derivatives can be used to create chiral stereogenic centers. 16) [37–39]. 17). Enantioselectivity is strongly inﬂuenced by an aromatic moiety of the catalyst, and a pentamethyl derivative was the catalyst of choice to achieve 91% ee .
Asymmetric Phase Transfer Catalysis by Keiji Maruoka